The parish of Arisipalayam was bifurcated from Shevapet in 1953 and was erected as St. Francis Xavier's parish. The chapel of St. Francis Xavier's Minor Seminary served as the parish church till 1991.
The New Cathedral was consecrated on 27th November 1991, and dedicated to Infant Jesus. This magnificent Cathedral was meticulously planned and carefully constructed with strenuous efforts by late Bishop Most Rev. Dr. Michael B. Duraisamy, as his last monument and gift to the diocese of Salem. Very Rev. Fr. S. Amalraj was asked to continue as the first Parish Priest of the Infant Jesus Cathedral parish, since he was already the Parish Priest of St. Xavier's Church at Arisipalayam. He was in-charge of the Parish till to 13th June 1992. Rev. Fr. S. Savari was appointed as the second Parish Priest.
He continued to be the parish Priest up to 20th July 1998. Rev. Fr. M.S. Martin succeeded Fr. S. Savari from 1998 till 2004. Fr. S. Pushpanathan was parish priest till 2009. Fr. A. Singarayan was parish priest up to June 2nd 2013. Fr. I. Gregory Rajan till the Present parish priest.
The cathedral Parish can be divided into two main areas: Arisipalayam and Peramanur. Omalur main Road is dividing these two areas. There are five sectors in Arisipalayam area: Arisipalayam, Mullakkadu, Saminathapuram, Angammal Colony and Pallapatti-Meiyanur. In Peramanur area also there are five sectors Peramanur, Chinnapudur, Sankar Nagar, Mostly teachers, Government Employees, Business people, a few doctors, lawyers and Engineers live in Peramanur area. Carpenters, Masons, Daily Coolies, Merchants, Teachers with few doctors and engineers reside at Arisipalayam area